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Dr. Dvora Sredni


    Place and Date of Birth:  Israel, January, 25, 1948.


    Marital Status:  Married + 3.




    1966-1970               B.Sc. Dept. of Life Science, Bar-Ilan University, Ramat-Gan.


    1970-1972               M.Sc. Dept. of Life Science, Bar-Ilan University, Ramat-Gan.


    1973-1981               Ph.D. Dept. of Life Science, Bar-Ilan University,  Ramat-Gan.




    Brief Chronology of Employment:


    1970-1972               Teaching Assistant, Dept. of Life Science, Bar-Ilan University.


    1973-1979               Instructor, Dept. of Life Science, Bar-Ilan University.


    1979-1981               Guest Worker, St. Elizabeth Hospital (NIH), Washington D.C.


    1981-1985               Researcher, National Virology Lab. Shiba Medical Center, Ramat-Gan, Israel.


    1985-1987               Guest Researcher, NINCDS, IDB, IRP, National Institute of Health, Bethesda, MD.


    1987-1991               Researcher, Cellular Immunology Lab. Meir Hospital, Kfar-Saba.


    1991-1992               Instructor, Interdisciplinary Dept. Bar-Ilan University, Ramat-Gan.


    1992-1999               Lecturer, Interdisciplinary Dept. Bar-Ilan University, Ramat-Gan.


    1. Deputy head of the Interdisciplinary Dept. Bar-ilan university, Ramt-Gan.


    1999-present           Senior Lecture, Interdisciplinary Dept. Bar-Ilan University, Ramat-Gan.


    2011-present           Head of the Interdisciplinary Dept. Bar-ilan university, Ramt-Gan.


    1. Sredni D., Grossman, S.,  Hydroperoxide isomers and keto hydroxy product from oxidation  of linoleic acid by eggplant lypoxigenase. Phyto Chemistry, 1980: 19: 1335:

    2. Rozenszajn, L.A.,  Goldman, J.,  Alter, A.,  Radnay, J.,  Sredni, D., Zemer, R.,  Lenz, R.,  T lymphocyte colony enhancing factor, LCEF, a non Species  specific factor generated by             human blood mononuclear cells and  murine   thymocytes. Exp. Hematol. 1989: 17: 441:

    3. Barda-Saad, M.,  Sredni, D.,  Zemer, R.,  Lenz, R.,  Rosenszajn, L.A.,   The role of LCEF in the T lymphocyte proliferation and colony formation. Harefuah, 1990: 118:  92:

    4. Lenz, R.,  Alter, A.,  Radnay, J.,  Goldman, J.,  Sredni, D.,  Rosenszajn, L.A.,           Stimulation of human T cell colony enhancement growth by Lymphocyte Colony                                                         Enhancement  Factor derived from lymphocyte subpopulation.  Nat. Immun. Cell       Growth Regulation. 1990: 9: 228:

    5. Fishman, P.,  Shoenfeld, Y.,  Hart, J.,  Zigelman, R.,  Shamir, Y.,  Feldberg, D.,  Inbar, O., Sredni, D.,  Djaldetti, M.,  Interleukin-3-like activity levels in pregnant women: possible modulation by progesterone. J. Rep. Immunol. 1992: 22: 211:

    6. 6. Fishman, P.,  Bakimer, R.,  Blank, M.,  Sredni, D.,  Djaldetti, M.,  Shoenfeld,    Y., The putative role of cytokines in the induction of primary anti-phospholipid syndrome in mice.  Clin. Exp. Immunol. 1992: 90: 266:

    7. Fishman,  P.,Kamashta, M., Ehrenfeld, M., Vianna, J., Hughes, G.R. Sredni, D., Zigelman, R., Sabo, G.,  Shoenfeld, Y.,   Interleukin-3   immunoassay in system  lupus erythematosus patients: preliminary data. Int. Arc. Allergy & Immunol. 1993: 100: 215-8:

    8. Mekori, Y.A., Baram, D., Goldberg, A., Hershkoviz, R., Reshef, T., Sredni, D.,              Nedocromil sodium inhibits T-cell function in vitro and in vivo. J. Allergy & Clin. immunol. 1993: 91: 817-24: (4.137)

    9. Dastgheib, K.,  Hikita, N.,  Sredni, B.,  Albeck, M.,  Sredni, D.,  Nussenblatt, R.B.,  Chan, C., Ocular  inflammation  stimulated  by the  immunomodulator AS101 [ammonium trichloro (dioxyethelene tellurate)]. Current Eye Res. 1994: 13: 603-10:

    10. Xu, R.H., Kim, J., Taira, M., Zhan, S., Sredni, D., Kung, H.,  A dominant negative bone  morphogenetic  protein 4 receptor causes neutralization in xenopus ectoderm. Biochem. Biophys. Res. Communication. 1995: 212(1): 212-9: (3.583)

    11. Enk, C.D.,  Sredni, D.,  Blauvelt, A.,  Katz, S.I., Induction  of IL-10 gene  expression in human keratinocytes by UVB exposure in vivo and vitro. J.  Immunol. 1995: 154: 4851-6:

    12. Xu,  R.H.,  Dong,  Z.,  Maeno,  M.,  Kim, J.,  Ueno, N.,  Sredni, D.,  Colburn, N.H. Kung, H.,  Involvement of ras/raf/ AP-1 in BMP-4 signaling during xenopus embryonic development . Proc. Natl. Acad. Sci. U S. 1996: 93: 834-8: (10.48)

    13. Xu, R.H., Kim, J., Taira, M., Lin, J.J., Zhang, C., Sredni, D., Evans, T., Kung, H.,  Differential regulation of neurogenesis by the two Xenopus  GATA-1 gens. Mol. Cell Biol. 1997: 17 (1): 436-43; (8.291)

    14. Sredni, D.,  Cytokines pattern in chronic fatigue syndrome. Chronic Fatigue Syndrome.  Yehuda, S., and Mostofsky, D.I., (Eds.) New york. Plenum Press. New York. 1997: 7: 131-59:

    15. Strassmann,  G.,  Kambayashi, T.,  Jacob, C.O.,  Sredni, D.,  The  immunomodulator  AS101  inhibits  IL-10  release and augment TNF and IL-1 release by  mouse and human  phagocytes. Cellular Immunology. 1997: 176: 180-5: (2.127)

    16. Xu, R.H., Kim. J., Taira, M., Sredni, D., Kung, H.,   Studies on the role of Fibroblast Growth Factor signaling in neurogenesis using Conjugated/Aged animal caps and Dorsal Ectoderm-Grafted Embryos. J. Neuroscience 1997: 17(18); 6892-8:

    17. Xu. R.H., Lechleider. R.J., Shin, H.M., Hao. S., Sredni. D., Roberts, A.B.,  Kung. H., Functional analysis of human Smad1: role of the amino-terminal domain. Biochem. Biophys. Res. Commun. 1999: 258(2): 366-73:

    18. Xu. R.H., Ault. K.T., Kim. J., Park. M.J., Hwang. Y.S., Peng. Y.,  Sredni, D., Kung, H.      Opposite Effects of FGF and BMP-4 on Embryonic Blood Formation: Roles of PV.1 and GATA-2. Dev. Biol. 1999: 208(8): 352-61:

    19. Sredni-Kenigsbuch, D.,  Kambayashi, T., Strassmann, G.,  Neutrophils augment the release TNFα from LPS-stimulated macrophages via Hydrogen peroxide.Immunol. Letters. 2000: 71: 97-102:

    20. Xu, R.H., Peng, Y., Fan, J., Yamagoe, Princler, G., Sredni, D., Ozato, K., Kung, H.,      Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction.      Developmental Dynamics 2000: 218: 628-635:

    21. Shohat, M., Hodak, E., Sredni, B.,  Shohat, B., Sredni, D., David, M., Cytokine profile of patients with mycosis fungoides and the immunumodulation effect of  AS101. Acta Derm. Venerol. 2001: 81(4): 255-257:

    22. Sredni-Kenigsbuch, D., Th1/Th2 cytokines in the Central Nervous System.  Int J Neurosci. 2002 ;112(6):665-703.

    23. Armony-Sivan, R., Eidelman, A.I., Lanir, A., Sredni, D., Yehuda, S., Iron Status and Neurobehavioral Development of Premature Infants. J. Perinatology. 2004, 10: 1038.

    24. Shohat M, Mimouni D, Ben-Amitai D, Sredni B, Sredni D, Shohat B, David M. In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101. Clin Exp Dermatol. 2005 Jul;30(4):432-4.

    25. Sredni B, Geffen-Aricha R, Duan W, Albeck M, Shalit F, Lander HM, Kinor N, Sagi O, Albeck A, Yosef S, Brodsky M, Sredni-Kenigsbuch D, Sonino T, Longo DL, Mattson MP, Yadid G. Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's disease models. FASEB J. 2007 Jun;21(8):1870-83. Epub 2007 Feb 21.

    26. Sredni-Kenigsbuch D, Shohat M, Shohat B, Ben-Amitai D, Chan CC, David M. The novel tellurium immunomodulator AS101 inhibits interleukin-10 production and p38  APK expression in atopic dermatitis. J Dermatol Sci. 2008 Jun;50(3):232-5. Epub 2008 Jan 31.

    27. Yehuda S, Sredni B, Carasso RL, Kenigsbuch-Sredni D. REM sleep deprivation in rats results in inflammation and interleukin-17 elevation. J Interferon Cytokine Res. 2009 Jul;29(7):393-8.

    28. Sredni-Kenigsbuch, D. Stress, Immunology, and Cytokines. (Int J Neurosci. In Press).




    Last Updated Date : 22/12/2022