English

ד"ר משה בוחר

דוא"ל
moshe.bocher@biu.ac.il
משרד
502/11
שעות קבלה
יום א' – שעה מדויקת בתיאום טלפוני מראש
קורות חיים

דרגה: מרצה בכיר נלווה-מומחה

 ראש תכנית דימות רפואי: יצירה והגשה של הקורסים הבאים: קורס CT, קורס MRI, סמינריון חידושים ברדיולוגיה. 

 

השכלה:

    MD, האוניברסיטה העברית ירושלים, רפואה, 1980

         נושא עבודת הדוקטורט: נושא עבודת ה-MD: "התכונות האנטיביוטיות של הצמח
         ארטמיזיה הרבה אלבה, הגדל במדבר יהודה" -1983         

         שם המנחה: פרופ' רות כהן

 

מינויים אקדמיים קודמים:

        המינוי                                שם האוניברסיטה                             שנת קבלת המינוי
        מדריך                       הדסה, האוניברסיטה העברית ירושלים             1991

       מרצה                       הדסה, האוניברסיטה העברית ירושלים              2001 

       מרצה בכיר קליני        הדסה, האוניברסיטה העברית ירושלים              2008

       מרצה בכיר קליני        פקולטה לרפואה אוניברסיטת בר-אילן              2017-2022

 

 

מקומות עבודה נוספים בהווה ובעבר:

   תפקיד ומקום עבודה קודם:

     ינואר 2016 - 2022 -  מנהל המכון לרפואה גרעינית בזיו, צפת, בהיקף משרה מלא. 

        תפקיד: תכנון והקמת מכון CT–PET החדש.

     יולי 2018 – 2021 - הפעלת מכון ה- CT –PET בזיו, והמכון לרפואה גרעינית.

     עדיין מפענח – חוץ של מיפויי CT-PET באותו מקום.

 

מקומות עבודה קודמים:

      עבדתי בהדסה כרופא מומחה ברפואה גרעינית, כולל קרדיולוגיה גרעינית ו-CT –PET, במשך כ-30 שנים (כולל התמחות ושנתיים השתלמות כמומחה בארה"ב).

 

במקביל לעבודתי בהדסה,  בשנים 1999-2015:

Consultant to research & development team of GE's (General Electric -GE Healthcare) nuclear medicine division in the process of creating imaging tools and software applications. Main projects: Hybrid imaging, SPECT-CT, PET-CT, the new CZT solid-state gamma detector, cardiac camera.

Member of the GE's advisory board, comprising of doctors and medical physicists, from major nuclear medicine departments around the world, that participate in futuristic discussions regarding developments that would take place in the coming years.

 

הדרכת סטודנטים לתארים מתקדמים בהדסה

  1. שמות תלמידי המוסמך MSC  
    סטודנטים שסיימו את עבודת המחקר:

שם התלמיד

שנת הסיום

מדריך שותף

אילן קלעי

2007

פרופ' דני גזית

 

  1. שמות תלמידי הדוקטור MD הדרכה לעבודות גמר: 

    סטודנטים שסיימו את עבודת הדוקטורט:

שם התלמיד

שנת הסיום

מדריך שותף

לואיג'י לאור

2000

פרופ' עומר בונה

יואב פרג

2000

פרופ' עומר בונה

נועה ורדי

2007

פרופ' עומר בונה

 

      הדרכת מתמחים למדעי יסוד:

שם התלמיד

שנת הסיום

סוג מחקר

רונית אגיד

2000

השוואת ממצאי UBO במוח ב-MRI  עם מיפוי גרעיני HMPAO בחולים דיכאוניים

 

סווטלנה אגרנוביץ

2000

הדמיה היברידית תפקודית-אנטומית של גידולים

 

עדי מיטל

2000

הדמיה היברידית תפקודית-אנטומית של גידולי ראש צוואר

 

דוד קיסלגוף

2002

שימוש ב-     SPECT-CT לאפיון מיפויי פרפוזיה של הריאה, בשאלה של תסחיף

 

מידע נוסף:

לימדתי בהדסה (האוניברסיטה העברית) שנים רבות. להלן הקורסים:

  1. Before 2001, basic topics in nuclear cardiology and nuclear medicine were given to fourth-year medical students as part of their radiology training.
  2. 2001-2004. Lectures in nuclear cardiology were given to sixth-year medical students during their rotation in the Cardiology department (Cardiology # 96848).
  3. 2006-2009. Lectures and reading sessions for fifth-year medical students during their course in radiology (Radiology # 96825).
  4. In May 2003, a one-week seminar on PET imaging at the School of Nuclear Medicine, Tata Cancer Institute, Mumbai, India, turned into a prolonged departmental seminar, preparing us for the coming of PET-CT in 2004.
  5. Lectures for residents and specialists in nuclear medicine at the school for continuing medical education at Tel-Aviv University.
  6. 2011 – Physics of PET.
  7. 2012-2015- Nuclear cardiology for medical students.

 

מחקר

השתתפתי במחקרי מפתח שעיצבו את פניה של הרפואה הגרעינית המודרנית העולמית. ראשית הייתי יועץ לצוות הפיתוח של חברת אלג'מס (המיזם המשותף של חברת אלסינט הישראלית וחברת GE – General Electric הבינלאומית), כשיצרנו את אב טיפוס המצלמה הגרעינית ההיברידית הקלינית הראשונה (SPECT, CT, PET), ושנה לאחר מכן את ה- PET-CT הקליני הראשון בעולם (של חברת GE). המחקר מוצא ביטוי במאמר:

 

Bocher, M., Balan, A., Krausz, Y., Shrem, Y., Lonn, A., Wilk, M., Chisin, R. (2000). Gamma Camera Mounted Anatomical X-Ray Tomography - Technology, System Characteristics and First Images. Eur. J. Nucl. Med 27(6):619-627.       

 

בהמשך, הייתי יועץ ומרכז מחקר לצוות הפיתוח של GE , כשיצרנו את המצלמה הקרדיאלית הגרעינית המהפכנית, מבוססת על טכנולוגיה חדישה של גלאי מצב מוצק מסוג CZT. המחקר מוצא ביטוי במאמר:

 

Bocher M, Blevis IM, Tsukerman L, Shrem Y, Kovalski G, Volokh L. A fast cardiac gamma camera with dynamic SPECT capabilities: design, system validation and future potential. Eur J Nucl Med Mol Imaging. 2010 Oct;37(10):1887-902.

 

        אציג להלן רעיון מחקר רחב היקף, שתכננתי משך שנים רבות, וקיבל צביון מעשי, כולל אישור של ועדת האתיקה בזיו, בשנה האחרונה. העבודה מתבצעת בשיתוף פעולה עם פרופ' ליאור רוקח, מנהל מחלקת הנדסת מערכות מידע באוניברסיטת בן גוריון, ועם ספי כהן, קצין-מהנדס מערכות מידע בצה"ל, ודוקטורנט העוסק בבינה מלאכותית, במחלקתו של פרופ' רוקח. ברשימת הפירסומים יש מאמר בתחום שפרסמנו לפני כשנה. (מספר 28 בפרסומים שפיטים)

 

Artificial Intelligence for automated classification of FDG PET-CT studies in oncological patients

The motivation behind focusing on FDG PET-CT in an oncological context, as an initial starting point:

Introduction: PET-CT is a hybrid technology that combines two devices, one is functional, i.e. PET, namely positron emission scanning, that provides high-signal biological information, such as the magnitude of tumor activity, along with structural technology, i.e. computed tomography (CT), which provides anatomical framework that allows the observed process to be located in the body. The amalgamation of the two types of information in a single radiologist mind, produces, in practice, unique insights, which exceed their diagnostic value, that would have been extracted from presenting the same information as two separate procedures. Therefore, shortly after the advent of PET-CT technology, about the year 2000, it became an indispensable tool for directing oncological care, mainly because of the high diagnostic power of hybrid technology, and also due to innovations that have since been developed in computerized image processing. Eventually, a unique diagnostic situation has emerged in PET-CT: Currently, in a glance, the diagnostician can arrive within a few minutes or even less, at a fairly accurate diagnosis (with over 90% accuracy), and yet it will take a long time, about half an hour to an hour, or even more, to perform the complete formal interpretation. This means that even before trying to adopt artificial intelligence methods for PET-CT diagnosis, the "automated diagnosis" is almost already possible with existing computer technology. In contrast, in any other radiological technology, such as CT or MRI, to reach a reliable general diagnosis in a short time, artificial intelligence shall be required from the start. In addition, we believe that the development of artificial intelligence applications in PET-CT may serve as a stage for developing artificial intelligence applications in stand-alone CT and MRI

 

Major medical imaging modalities such as CT, PET-CT, or MRI require considerable physician time for optimal diagnosis. In recent years, the problem has been exacerbated by the constant increase in the complexity involved in current radiological studies. Furthermore, the relative burden on physician time is becoming more noticeable, due to considerably expediting data collection time, following the initiation of more sophisticated and faster technologies, to the extent that physician time is currently identified as the main "bottleneck" of the diagnostic process. This state of affairs creates a significant obstacle to the ability of the medical community to use imaging, even in countries where those technologies are relatively accessible. Therefore, it also significantly increases the costs of the health care system. In addition, this phenomenon creates a situation of crisis, sometimes semi-subconscious, to the global imaging industries, as it restricts the use of their products, and indirectly impedes their constant technological effort to create devices that shorten the imaging time. As a result, there is a strong need to solve the problem, or at least to alleviate it, in both the public health and the global industrial domains. In addition, there is hidden or sometimes even apparent pressure on the diagnosticians, by medical administrations, to shorten the diagnosis time, regardless of the growing complexity. This pressure results in reduced diagnostic quality, sometimes to the point of introducing interpretation errors. The pressure on the doctors also causes a tendency for the imaging departments to degenerate, as doctors find no time for updating, quality control, development, and research. There is also a concern about impairing the quality of life, peace of mind, and possibly the health of radiologists.   

 

It should be noted that, despite huge technological and computational developments in the field of imagery in recent years, which included attempts, some of them successful, to ease and speed up the diagnostic process, most of the problems and major challenges involved remained unanswered. In recent years, statements of a desire to solve the problem through artificial intelligence have often been made. Still, so far, to our knowledge, no system has yet been shown to be able to routinely address the problem in its general form. This serves to indicate the magnitude of the challenge involved in finding quality solutions at a meaningful level

 

Our Primary objectives:

Building a computerized workspace will allow the radiologist to reach a complete medical diagnosis with a higher degree of confidence within a much shorter time compared to what is required today.

Eventually, developing an AI-based, alternative working environment for today's standard that will achieve automated diagnosis, initially as an aid to the radiologist and ultimately, in the future, as an independent diagnostic system.

 

Recruitment of imaging data:

A few months back, we applied to the Ethics committee of Ziv Medical Center, asking for permission to process 10,000 FDG PET-CT studies with their diagnostic report and all relevant clinical data using AI tools that we intend to build at the Department of Engineering at Ben-Gurion University. Eventually, we were granted such permission, authorized by the committee, signed by Prof. Salman Zarka, Director of Ziv Medical Center.

Our patient population includes patients with cancer, referred for PET-CT FDG study by oncologists/ hematologists, most of them are from the north of Israel. Since we are ultimately seeking a general diagnostic performance, we intend to include all oncological indications without restriction on the type of cancer, without age restriction, for both females and males. We intend to include studies with and without Iodine contrast injection for the CT part. Those patients will have at least one PET-CT study formally diagnosed by an expert diagnostician.

 

Preliminary/current work

 

  1. Most PET-CT (yet, not all) studies included were acquired on GE's 5 –rings IQ PET-CT camera.
  2. A group of 7 radiologists manually labeled portions of the reports according to a set of 8 possible outcomes.
  3. Anonymized reports (labeled and unlabeled) and their corresponding imaging are transferred to the Department of Engineering at Ben-Gurion University, to the team of Prof. Lior Rokach, a principal co-investigator of this study.
  4. NLP (Natural Language Processing) methods: The textual radiology reports are automatically analyzed, and the findings are extracted and associated with the corresponding images. Our current models reach an AUC (Area under the ROC Curve) performance of 0.9148.
  5. An ensemble of CNN (convolutional neural network) models with various and heterogeneous architectures is used to select findings from a possible list of findings.

 

Next stage of work:

  1. Automated NLP text classification for radiology reports written in Hebrew.
  2. Weakly-Supervised Medical Image Segmentation: In the case of a fully supervised setting, the dataset consists of images and their corresponding pixel-level class-specific annotations (expensive pixel-level annotations). However, in the weakly-supervised setting, the dataset consists of image-wise labels and not pixel-wise. We suggest using pre-trained general models and specific models for selected organs, in particular: Brain segmentation, Lung, and Cardiac. Pancreas Segmentation and Liver Segmentation, Muscle-skeletal, and Bowels
  3. Lesion Segmentation and Tumor Segmentation in general and for selected organs specified above.
קורסים

  • פיסיקה וטכנולוגיה של  CT

  • פיסיקה וטכנולוגיה של MRI

  • סמינריון "חידושים בדימות"

פרסומים

 

     א. פרסומים שפיטים                                             Refereed Publications

        

        מאמרים בכתבי עת                                             Articles in periodicals

 

Contribution to the study

A-Initiator of the study; B- Performing the study; C-Writing the manuscript draft; D-Reviewing the draft

 

  1. Nitzan, M., Mahler, Y., Yaffe, S., Marziano, R., Bocher, M., & Chisin, R. (1992). ECG gated radionuclide plethysmography — a method for the assessment of pulmonary systolic blood volume increase. Clinical Physics and Physiological Measurement, 13(1), 21-28. https://doi.org/10.1088/0143-0815/13/1/002  
  2. Chisin, R., Pietrzyk, U., Sichel, J.Y., Rubinstein, R., Yaffe, S., Bocher, M., Gomori, J.M., & Karger, H. (1993). Registration and display of multimodal images: applications in the extracranial head and neck region. Journal of Otolaryngology, 22, 214-219.   
    The journal was closed in 2007. JCR: IF (2007) = 0.49, 27/30 Otorhinolaryngology, Q4; SJR: N/A
  3. Bocher, M., Issachar, D., Zabari, M., Karger, H., & Chisin, R. (1994). Original article. The use of iridium-191m for lung blood-flow imaging. European Journal of Nuclear Medicine, 21(5), 427-431. https://doi.org/10.1007/BF00171418
  4. Schechter, D., Milgater, E., Bocher, M., Shimon, D.V., Borman, J.B., Rozenman, Y., Merin, G., Gotsman, M.S., Weiss, A.T., & Chisin, R. (1994). Value of dobutamine nitroglycerine radionuclide ventriculography in predicting revascularization effects on ventricular function. Journal of Cardiovascular Surgery, 35(1), 81-84.
  5. Nizan, N., Mahler, Y., Schechter, D., Yaffe, S., Bocher, M., & Chisin, R. (1994). A measurement of pulmonary blood volume increase during systole in humans. Physiological Measurement, 15(4), 489-498. https://doi.org/10.1088/0967-3334/15/4/010
  6. Bonne, O., Krausz, Y., Shapira, B., Bocher, M., Karger, H., Gorfein, M., Chisin, R., & Lerer, B. (1996). Increased cerebral blood flow in depressed patients responding to electroconvulsive therapy. Journal of Nuclear Medicine, 37(7), 1075-1080. https://jnm.snmjournals.org/content/37/7/1075.long

JCR: IF = 2.3, 44/85 Physiology, Q3; SJR: N/A

Contribution: B, D

 

Contribution: B, D

 

JCR: IF = 8.6, 8/204 Radiology, Nuclear Medicine & Medical Imaging, Q1; SJR: 9/335 Radiology, Nuclear Medicine and Imaging, Q1

Contribution: A, B, C

 

JCR: IF =1.4, 72/96 Peripheral Vascular Disease, Q3; SJR: 208/381 Cardiology and Cardiovascular Medicine, Q2

Contribution: D

 

JCR: IF = 2.3, 44/85 Physiology, Q3; SJR: 73/148 Biophysics, Q2

Contribution: B, D

 

JCR: IF = 9.1, 6/204 Radiology, Nuclear Medicine & Medical Imaging, Q1; SJR: 14/335 Radiology, Nuclear Medicine and Imaging, Q1

Contribution: B, D

 

  1. Krausz, Y., Levy, M. Antebi, E., Bar-Ziv, J., Bocher, M., & Chisin, R. (1997). Liver Hemangiona: A Perioperative Technetium-99M-RBC SPECT Correlation. Clinical Nuclear Medicine, 22(1), 35-37. https://doi.org/10.1097/00003072-199701000-00008
  2. Schechter, D., Sapoznikov, D., Luria, M.H., Mendelson, S., Bocher, M., & Chisin, R. (1998). Heart rate variability as a marker of myocardial perfusion. Cardiology, 90(4), 239-243. https://doi.org/10.1159/000006851  
  3. Landesberg, G., Wolf, Y., Schechter, D., Mosseri, M., Weissman, C., Anner, H., Chisin, R., Luria, M.H., Kovalski, N., Bocher, M., Erel, J., & Berlatzky, Y. (1998). Preoperative thallium scanning, selective coronary revascularization, and long-term survival after carotid endarterectomy. Stroke, 29(12), 2541-2548. https://doi.org/10.1161/01.str.29.12.2541
  4. Bocher, M., Balan, A., Krausz, Y., Shrem, Y., Lonn, A., Wilk, M., & Chisin, R. (2000). Gamma camera mounted anatomical X-ray tomography — Technology, system characteristics and first images. European Journal of Nuclear Medicine, 27(6), 619-627. https://doi.org/10.1007/s002590050555
  5. Brown., K., Tang, H.R., Hatner, R.S., Bocher, M., Ratzlaff, N.W., Kadkade, P.J., Hasegawa, B.H., & Botvinick, E.H. (2000). Intrinsic dual-Energy processing of myocardial perfusion images. Journal of Nuclear Medicine, 41(7), 1287-1297.  https://jnm.snmjournals.org/content/jnumed/41/7/1287.full.pdf
  6. Mishani, E., Bocher, M., Ben David, I., Rozen, Y., Laki, D., Marciano, R., & Chisin, R. (2001). [C-11] Choline – automated preparation and clinical utilization. Journal of Labelled Compounds and Radiopharmaceuticals, 44, 379. https://doi.org/10.1002/jlcr.25804401134
  7. Bocher, M., Chisin, R., Parag, Y., Freedman, N., Meir Weil, Y., Lester, H., Mishani, E., & Bonne, O. (2001). Cerebral activation associated with sexual arousal in response to a pornographic clip: A 15O-H2O PET study in heterosexual men. NeuroImage, 14, 105-117. https://doi.org/10.1006/nimg.2001.0794
  8. Bocher, M., Shrem, Y., Tappisser, A., Klein, M., Schechter, D.,  Taylor, A. Jr., & Chisin, R. (2001). Technetium-99m Mercaptoacetyltriglycin clearance: Comparison of camera-assisted methods. Clinical Nuclear Medicine, 26(9), 745-750. https://doi.org/10.1097/00003072-200109000-00001
  9. Bonne, O., Louzoun, Y., Aharon, I., Krausz, Y., Karger, H, Lerer, B., Bocher, M., Freedman, N., & Chisin, R. (2003). Cerebral blood flow in depressed patients: a methodological comparison of statistical parametric mapping and region of interest analyses. Psychiatry Research- Neuroimaging, 122(1), 49-57. https://doi.org/10.1016/S0925-4927(03)00109-4
  10. Landesberg, G., Mosseri, M., Wolf, Y.G., Bocher, M., Basevitch, A., Rudis, E., Izhar, U., Anner, H., Weissmann, C., & Berlatzky, Y. (2003). Preoperative thallium scanning, selective coronary revascularization, long-term survival after major vascular surgery. Circulation, 108, 177-183. https://doi.org/10.1161/01.CIR.0000080292.11186.FB
  11. Bonne, O., Gilboa, A., Louzoun, Y., Kempf-Sherf, O., Katz, M., Fishman, Y., Ben-Nahum, Z., Krausz, Y., Bocher, M., Lester, H., Chisin, R., & Lerer, B. (2003). Cerebral blood flow in chronic symptomatic mild traumatic brain injury. Psychiatry Research- Neuroimaging, 124(3), 141-152. https://doi.org/10.1016/S0925-4927(03)00109-4
  12. Landesberg, G., Mosseri, M., Shatz, V., Akopnik, I., Bocher, M., Mayer, M., Anner, H., Berlatzky, Y., & Weissman, C. (2004).Cardiac troponin after major vascular surgery: the role of perioperative ischemia, preoperative thallium scanning, and coronary revascularization. Journal of the American College of Cardiology, 44(3), 569-575. https://doi.org/10.1016/j.jacc.2004.03.073
  13. Krausz, Y., Freedman, N., Lester, H., Newman, J.P., Barkai, G., Bocher, M., Chisin, R., & Bonne, O. (2004). Regional cerebral blood flow in patients with mild hypothyroidism. Journal of Nuclear Medicine, 45(10), 1712-1715. https://jnm.snmjournals.org/content/45/10/1712.long
  14. Krausz, Y., Freedman, N., Lester, H., Barkai, G., Levin, T., Bocher, M., Chisin, R., Lerer, B., & Bonne, O. (2007). Brain SPECT study of common ground between hypothyroidism and depression. International Journal of Neuropsychopharmacology, 10(1), 99-106. https://doi.org/10.1017/s1461145706006481
  15. Landesberg, G., Berlatzky, Y., Bocher, M., Alcalai, R., Anner, H., Ganon-Rozental, T., Luria, M.H., Akopnik, I., Weissman, C., & Mosseri, M. (2007). A clinical survival score predicts the likehood to benefit from preoperative thallium scanning and coronary revascularization before major vascular surgery. European Heart Journal, 28(5), 533-539. https://doi.org/10.1093/eurheartj/ehl390
  16. Ilovich, O., Billauer, H., Dotan, S., Freedman, N.M., Bocher, M., & Mishani, E. (2010). Novel and Simple Carbon-11-Labeled Ammonium Salts as PET Agents for Myocardial Perfusion Imaging. Molecular Imaging and Biology, 13, 128-139. https://doi.org/10.1007/s11307-010-0336-7
  17. Bocher, M., Blevis, I.M., Tsukerman, L., Shrem, Y., Kovalski, G., & Volokh, L. (2010). A fast cardiac gamma camera with dynamic SPECT capabilities: design, system validation and future potential. European Journal of Nuclear Medicine, 37(10), 1887-1902. https://doi.org/10.1007/s00259-010-1488-z
  18. Ilovich, O., Abourbeh, G., Bocher, M., Freedman, N., Billauer, H., Dotan, S., Danenberg, H.D., & Mishani, E. (2012). Structure—activity relationship and preclinical evaluation of carbon-11-labeled ammonium salts as PET—myocardial perfusion imaging agents. Molecular Imaging & Biology, 14(5), 625-36. https://doi.org/10.1007/s11307-011-0539-6  
  19. Orevi, M., Freedman, N., Mishani, E., Bocher, M., Jacobson, O., & Krausz, Y. (2014). Localization of parathyroid adenoma by ¹¹C-choline PET/CT: preliminary results. Clinical Nuclear Medicine, 39(12), 1033-1038. https://doi.org/10.1097/RLU.0000000000000607
  20. Weinstein, A. M., Freedman, N., Greif, J., Yemini, Z., Mishani, E., London, E., ... & Bocher, M. (2016). Negative association of pretreatment cigarette use with smoking‐induced striatal dopamine release in smokers receiving bupropion treatment. The American Journal on Addictions, 25(6), 486-492. https://doi.org/10.1111/ajad.12419
  21. Tshori, S., Bocher, M., Yuzefovich, B., Rubinstein, R., Gross, D. J., Fraenkel, M., & Krausz, Y. (2017). Diagnostic computed tomography coregistration with in-111-dtpa-octreotide single photon emission tomography/low-dose computed tomography. Journal of Computer Assisted Tomography, 41(3), 499-504. https://doi.org/10.1097/RCT.0000000000000527                                           JCR: IF = 1.0, 160/204 Radiology, Nuclear Medicine & Medical Imaging, Q4; SJR: 186/335 Radiology, Nuclear Medicine and Imaging, Q3
  22. Cohen, S., Lior, E., Bocher, M., & Rokach, L. (2024). Improving severity classification of Hebrew PET-CT pathology reports using test-time augmentation. Journal of Biomedical Informatics, 149, 104577. https://doi.org/10.1016/j.jbi.2023.104577
    JCR: IF = 4.0, 46/170 Computer Science, Interdisciplinary Applications, Q2; SJR: 25/137 Health Informatics, Q1

JCR: IF = 10.0, 4/204 Radiology, Nuclear Medicine & Medical Imaging, Q1; SJR: 132/335 Radiology, Nuclear Medicine and Imaging, Q2

Contribution: A, B, C

 

JCR: IF = 1.9, 125/222 Cardiac & Cardiovascular Systems, Q3; SJR: 179/381 Cardiology and Cardiovascular Medicine, Q2

Contribution: D

 

JCR: IF = 7.9, 4/96 Peripheral Vascular Disease, Q1; SJR: 14/154 Neuroscience, Q1

Contribution: B, D

 

JCR: IF = 8.6, 8/204 Radiology, Nuclear Medicine & Medical Imaging, Q1; SJR: 9/335 Radiology, Nuclear Medicine and Imaging, Q1

Contribution: A, B, C

 

JCR: IF = 9.1, 6/204 Radiology, Nuclear Medicine & Medical Imaging, Q1; SJR: 14/335 Radiology, Nuclear Medicine and Imaging, Q2

Contribution: B, D

 

JCR: IF = 0.9, 95/106 Chemistry, Analytical, Q4; SJR: 212/335 Radiology, Nuclear Medicine and Imaging, Q3

Contribution: B, D

 

JCR: IF = 4.7, 1/15 Neuroimaging, Q1; SJR: 10/185 Neurology, Q1

Contribution: A, C

 

JCR: IF = 10.0, 4/204 Radiology, Nuclear Medicine & Medical Imaging, Q1; SJR: 132/335 Radiology, Nuclear Medicine and Imaging, Q2

Contribution: A, B, C

 

JCR: IF = 2.1, 148/279 Psychiatry, Q3; SJR: 222/578 Psychiatry and Mental Health, Q2

Contribution: B, D

 

JCR: IF = 35.6, 1/96 Peripheral Vascular Disease, Q1; SJR: 2/381 Cardiology and Cardiovascular Medicine Physiology, Q1

Contribution: B, D 

 

JCR: IF = 2.1, 148/279 Psychiatry, Q3; SJR: 222/578 Psychiatry and Mental Health, Q2

Contribution: D

 

JCR: IF = 21.7, 1/381 Cardiac & Cardiovascular Systems, Q1; SJR: 1/381 Cardiology and Cardiovascular Medicine, Q1

Contribution: B, D

 

JCR: IF = 9.1, 6/204 Radiology, Nuclear Medicine & Medical Imaging, Q1; SJR: 14/335 Radiology, Nuclear Medicine and Imaging, Q2

Contribution: D

 

JCR: IF = 4.5, 42/280 Clinical Neurology, Q1; SJR: 77/578 Psychiatry and Mental Health, Q1

Contribution: D

 

JCR: IF = 38.1, 2/222 Cardiac & Cardiovascular Systems, Q1; SJR: 9/381 Cardiology and Cardiovascular Medicine, Q1

Contribution: B, D

 

JCR: IF = 3.0, 52/204 Radiology, Nuclear Medicine & Medical Imaging, Q2; SJR: 93/335 Radiology, Nuclear Medicine and Imaging, Q2

Contribution: A, D

 

JCR: IF = 8.6, 8/204 Radiology, Nuclear Medicine & Medical Imaging, Q1; SJR: 9/335 Radiology, Nuclear Medicine and Imaging, Q1

Contribution: A, B, C

 

JCR: IF = 3.0, 54/204 Radiology, Nuclear Medicine & Medical Imaging, Q2; SJR: 93/335 Radiology, Nuclear Medicine and Imaging, Q2

Contribution: A, B, D

 

JCR: IF = 10.0, 4/204 Radiology, Nuclear Medicine & Medical Imaging, Q1; SJR: 132/335 Radiology, Nuclear Medicine and Imaging, Q2

Contribution: A, D

 

JCR: IF = 2.5, 24/56 Substance Abuse, Q2; SJR: 63/313 Clinical Psychology, Q1 Contribution: A

 

Contribution: D

 

Contribution: A, B, D

 

    ב. פרסומים שאינם שפיטים                                 non-refereed publications

 

  1. Bocher, M., & Erel, J. (1992). Use of technetium-99m carriers for myocardial perfusion imaging. Harefuah, 122(10), 657-660. (In Hebrew).

          Contribution: A, C

     

  2. Moutiris, J.A., Bocher, M., Kramer, A., & Schechter, D. (1994). Nuclear cardiology imaging in the assessment of myocardial perfusion and in the evaluation of coronary artery disease. Cyprus Medical Journal, 12, 15-21.     

          Contribution: A, D

     

  3. Bocher, M., Schechter, D., Kramer, A., & Chisin, R. (1994). Tc-99m-MIBI scintigraphy can rule out myocardial infarction when ECG is misleading. Medizinskaya Radiologiya, 6, 61-62. (In Russian).

    Contribution: A, B, C

     

  4. Bocher, M., & Mishani, E. (2000). The contribution of positron emission tomography to the treatment of cancer patients. Harefuah, 139(1-2), 64-67. (In Hebrew). 

          Contribution: A, C

     

  5. Levin, N., Soffer, D., Biran, I., Gomori, M., Bocher, M., Blumen, S., Abramsky, O., Segal, R., & Lossos, A. (2008). Leukoencephalopathy with neuroaxonal spheroids (LENAS) presenting as frontotemporal dementia. The Israel Medical Association Journal, 10(5), 386-387.

          Contribution: B, D 

 

 

    ג. הרצאות בכנסים מדעיים  PAPERS PRESENTED AT SCIENTIFIC CONFERENCES

 

  1. Nitzan, M., Chisin, R., Yaffe, S., Marziano, R., Bocher, M., & Mahler, Y. (1991). Assessment of pulmonary systolic blood volume increase by ECG-gated radionuclide plethysmography. Proceedings of the World Congress on Medical Physics, Kyoto, Japan, p. 230.

     

  2. Chisin, R., Sichel, J.Y., Rubinstein, R., Yaffe, S., Bocher, M., Gomori, J.M., & Karger, H. (1992). Registration and display of multimodal images of the head and neck region. The Drommelschlager Conference and Postgraduate Course on Head and Neck Imaging, Jerusalem, Israel.

     

  3. Nitzan, M., Mahler, Y., Yaffe, S., Bocher, M., Karger, H., & Chisin, R. (1992). Pulmonary plethysmography using radionuclide chest scintigraphy. Proceedings of 14th Annual International Conference IEEE MBS, Paris, pp. 110-111.

     

  4. Rosenberg, C., Erel, J., Schechter, D., Bocher, M., Atlan, H., & Chisin, R. A. (1992). Neural network that learns to interpret myocardial planar thallium scintigrams. Hadassah, Research Day (Poster).

     

  5. Bonne, O., Krausz, Y., Shapira, B., Kempf, O., Tubi, N., Chisin, R., Bocher, M., & Lerer, B. (1993). HMPAO-SPECT and neuropsychological testing in depressed patients before and after ECT. First National Conference of the Israel Society of Biological Psychiatry, Kfar Giladi, Israel.

     

  6. Krausz, Y., Bonne, B., Shapira, Z., Meiner, O., Kempf, N., Tubi, H., Karger, H., Bocher, M., Chisin, R., & Lerer, B. (1993). HMPAO-Brain SPECT imaging in depressed patients before and after ECT. European Association of Nuclear Medicine Congress, Lausanne, Switzerland.

 

  1. Mahler, Y., Nitzan, M., Yaffe, S., Schechter, D., Bocher, M., Gross, C., Karger, H., & Chisin, R. (1993). Assessment of blood volume change in the lungs using radionuclide scintigraphy. Annual Symposium on Medical Physics in Memory of Edward W. Joseph. Jerusalem, Israel.

     

  2. Schechter, D., Bocher, M., Mosseri, M., Krausz, Y., Berlatsky, Y., Gotsman, M.S., & Chisin, R. (1993). Dipyridamole associated transient motor neurological deficit: evidence for cerebral vasculature steal phenomenon ? 4th International Conference on Non-Invasive Cardiology. Limassol, Cyprus.

     

  3. Schechter, D., Goldfarb, A., Gilon, D., Bocher, M., Rein, A.J.J.T., Gotsman, M.S., Rachmilewitz, E.A., & Chisin, R. (1993). Right ventricular dysfunction and pulmonary arterial pressure in beta-thalassemia: an exercise radionuclide ventriculographic and echo doppler correlation. 4th International Conference on Non-Invasive Cardiology. Limassol, Cyprus.

     

  4. Schechter, D., Milgalter, E., Bocher, M., Shimon, D.V., Borman, J.B., Rozenman, Y., Merin, G., Gotsman, M.S., Weiss, A.T., & Chisin, R. (1994). Value of Dobutamine Nitroglycerine Radionuclide Ventriculography in Predicting Revascularization Effects on Ventricular Function. International Society of Cardio-Thoracic Surgeons (ISCTS) Fourth World Congress, Jerusalem, Israel.

     

  5. Schechter, D., Goldfarb, A., Gilon, D., Bocher, M., Rein, A.J.J.T., Gotsman, M.S., Rachmilewitz, E.A., & Chisin, R. (1994). Right Ventricular Dysfunction and Pulmonary Arterial Pressure in Beta-Thalassemia: An Exercise Radionuclide Ventriculographic and Echo Doppler Correlation. The Second Congress of the Israeli Society of Cardiology. April 26, Tel-Aviv, Israel.

 

  1. Schechter, D., Sapoznikov, D., Bocher, M., Shibly, N., Chisin, R., Kramer, A., Gotsman, M.S., & Luria, M. (1995). Relation of Heart Rate Variability to Exercise Dynamics and Thallium Perfusion Scanning. Fifth International Congress on Non-Invasive Cardiology. Tel Aviv, Israel.

     

  2. Schechter, D., Bocher, M., Admon, D., Kramer, A., Krausz, Y., Rubinstein, R., Gotsman, M.S., & Chisin, R. (1995). Intravenous dipyridamole-induced ST segment elevation. The 5th International Conference on non-invasive Cardiology, Tel-Aviv, Israel.

     

  3. Bocher, M., Klein, M., Krausz, Y., Rubinstein, R., Schechter, D., Shrem, Y., & Chisin, R. (1996). Hadassah Hospital experience with the “GOSH” renal scintigraphy software package.  The Sixth Mediterranean Meeting on Nuclear Medicine and Radiopharmaceuticals: Radionuclides for Nephro-Urology. Eilat, Israel.

     

  4. Brown, J.K., Tang, H.R., Bocher, M., Ratzlaff, N.W., Hasagawa, B.H., Botvinic, E.H., & Hattner, R.S. (1997). Characterizing the local impact of attenuation in myocardial SPECT using Intrinsic Dual energy Processing (IDEP). Society of Nuclear Medicine annual meeting, San-Antonio Texas.

     

  5. Bocher, M., Kusubov, T.E., & Nordahl, T.E. (1998). Seasonal Variations of Hemispheric Asymmetries. Cognitive Neuroscience Society Annual Meeting,  San Francisco.

     

  6. Bocher, M., Kusubov, N., & Nordahl, T.E. (1998). Seasonal Variations in Right-To-Left Metabolic Balance in the Prefrontal Cortex. Society of Biological Psychiatry Annual Meeting, Toronto.

     

  7. Segall, G.M., Carlisle, M., & Bocher, M. (1998). Prospective Comparison of FDG PET with a gamma camera versus a dedicated PET scanner in patients with cancer. The Society of Nuclear Medicine 23rd Annual Western Regional Meeting, Long Beach CA.

     

  8. Bonne, O., Krausz, Y., Kempf, O., Brandes, D., Louzoun, Y., Bocher, M., Fishman, Y., Ben-Nahum, Z., Lehrer. B., Shalev, A.Y., & Chisin, R. (1999). The Sequelae of Trauma: Cognitive Deficit and Cerebral Blood Flow. Fourth Jerusalem Imaging Meeting.

     

  9. Panet, R., Stav, I., Bocher, M., & Chisin, R. (1999). Enhanced Uptake of (H-3) Triphenylphosphonium and (Tc-99) Sestamibi in Malignant Cell lines: a Function of increased Cell and Mitochondrial Membrane Potentials. The 46th annual meeting of the Society of Nuclear Medicine, Los Angeles CA.

     

  10. Segall, G.M., Carlisle, M., & Bocher, M. (1999). Prospective comparison of coincidence imaging versus dedicated PET in patients with cancer. The 46th Annual Meeting of the Society of Nuclear Medicine, Los Angeles CA.

     

  11. Bocher, M., Balan, A., Krausz, Y., Shrem, Y., Lonn, A., Wilk, M., & Chisin, R. Gamma Camera Mounted Anatomical X-Ray Tomography - Technology, System Characteristics and First Images. The 46th Annual Meeting of the Society of Nuclear Medicine, Los Angeles, CA.

     

  12. Segal, R., Chisin, R., & Bocher, M. (2001). Hawkeye system®. Scintigrapic and anatomic imaging in one. Neurosurgery, Australia.

     

  13. Bocher, M., Bonne, O., Parag, Y., Freedman, N., Meir-Weill, Y., Lester, H., Mishani, E., & Chisin, R.) 2001). Cerebral activation associated with sexual arousal in response to a pornographic clip: a 15O-H2O PET study in heterosexual men. 48th Annual Meeting of the Society of Nuclear Medicine, Toronto, Canada.

 

  1. Krausz, Y., Lester, H., Bar-Haim, N., Freedman, N., Bocher, M., Chisin, R., & Bonne, O.(2001). Brain SPECT Imaging in Hypothyroidism. 48th Annual Meeting of the Society of Nuclear Medicine, Toronto, Canada.

     

  2. Chisin, R., Bocher, M., Freedman, N., Lester, H., Shalev, A., & Bonne, O.A. (2001). Symptom provocation brain PET study in PTSD patients. MEDAX 2001, Tel-Aviv, Israel.

     

  3. Bocher, M., Cohen, M., Freedman, N., & Chisin, R. (2001). Hadassah hospital experience using FDG-PET for localization of an epileptic focus in patients with intractable epilepsy. MEDAX 2001, Tel-Aviv, Israel.

     

  4. Bocher, M., Weininger, J., Yuzefovich, B., Wilk, M., & Chisin, R. (2002). Evaluation of reconstruction methods of 18F-FDG PET images on a gamma camera with X-Ray transmission. 5th International Congress of Nuclear Oncology & 15th National Congress of Turkish Society of Nuclear Medicine, Kusadasi, Turkey.

     

  5. Krausz, Y., Keidar, Z., Kogan, E.M., Even-Sapir, E.M., Bar-Shalom, R., Engel, A., Rubinstein, R., Sachs, J., Bocher, M., Chisin, R., & Israel, O. (2002). The value of hybrid imaging using SPECT/CT with 111 in pentetreotide in assessment of neuroendocrine tumors. SNM 49th Annual Meeting, Los Angeles, CA.

     

  6. Klein, M., Bocher, M., & Chisin, R. (2002). Contribution of combined SPECT-CT in sentinel lymph node (SLN) localization by lymphoscintigraphy (LS). The SNM 49th Annual Meeting, Los Angeles, CA.

     

  7. Bocher, M., Weininger, J., Yuzefovich, B., Wilk, M., & Chisin, R. (2002). Comparison of reconstruction methods of 18-F-FDG PET images on a gamma camera with X-Ray transmission. SNM 49th Annual Meeting, Los Angeles, CA.

     

     

  8. Chisin, R.G., Freedman, N., Rubinstein, R., Mishani, E., Bocher, M., Lester, H., Shoshan, Y., Gomori, J.M., & Siegal, T. (2002). Can C-11 choline PET (CHOL-PET) contribute to differentiating recurrent high-grade brain tumor from post-radiation necrosis (PRN)? SNM 49th Annual Meeting, Los Angeles, CA.

     

  9. Bocher, M., Krausz, Y., Kisselgoff, D., Weininger, J., & Chisin, R. (2003). Lung perfusion scintigraphy: change in interpretation and confidence using hybrid SPECT/CT. 50th Annual Meeting of the Society of Nuclear Medicine, New Orleans, Louisiana, USA.

     

  10. Bar-Haim Erez, A., Katz, N., Bocher, M., Lester, H., Chisin, R., Freedman, N., Cohen, A., & Abramsky, O. (2003). Neural mechanism of visual attention in unilateral spatial neglect following stroke: a (O-15)-water brain activation PET study. 50th Annual Meeting of the Society of Nuclear Medicine, New Orleans, Louisiana, USA.

     

  11. Krausz, Y., Klein, M., Uziely, B., Rubinstein, R., Bocher, M., & Chisin, R. (2004).Impact of SPECT/CT on assessment of I131-avid sites in Differentiated Thyroid Cancer. The Society of Nuclear Medicine 51st Annual Meeting, Philadelphia, Pennsylvania, USA.

     

  12. Orevi, M., Gofrit, O.N., Freedman, N., Mishani, E., Klein, M., Bocher, M., Marciano, R., Krausz, Y., & Chisin, R. (2006). Pitfalls in interpretation of C-11 Choline PET and PET/CT in urinary tract and prostate cancer. The Society of Nuclear Medicine 53rd Annual Meeting, San Diego, California, USA.

     

  13. Farkash, G., Kenig, T., Yuzefovich, B., Sachs, J., Grabnic, M., & Bocher, M. (2006). Volumetric Quantitation of Left Ventricular Perfusion and Function from Myocardial Perfusion SPECT: Validation of a New Algorithm. Society of Nuclear Cardiology, Montreal, Canada.

     

  14. Orevi, M. Bocher, M., Klein, Y., Krausz, S., Tshori, R., Rubinstein, R., & Chisin, R. (2009). F18-FDG PET/CT in FUO: a pictorial essay. The Israel Society of Nuclear Medicine, Dead Sea, Israel.

     

  15. Tshori, S., Yuzefovich, B., Bocher, M., Rubinstein, R., Gross, D., Fraenkel, M., Chisin, R., & Krausz, Y. (2011). Diagnostic CT co-registration with 111In-DTPA-Octreotide SPECT/CT scintigraphy. The Society of Nuclear Medicine 58th Annual Meeting, San Antonio, Texas, USA. 

תאריך עדכון אחרון : 05/08/2025